Population
18 chronically instrumented lambs (7 fetal and 11 newborn aged 1 to 15 days)
Comparison
Infusion of [1-13C]lactate vs Comparison between fetal and newborn lambs
Design
Preclinical
Authors
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Lactate may fuel perinatal myocardium in lambs; leaves open translation to human neonates and clinical relevance.
Lactate remains an important energy source for the myocardium both before birth and in the first 2 weeks after birth in lambs, with oxidation potentially attenuated by fatty acids.
Bartelds et al. (1999) studied this question.
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