Why the study?
Does chronic exercise produce intrinsic changes on automatism, conduction, and refractoriness in isolated rabbit hearts?
Population
Isolated rabbit hearts from trained and untrained animals
Comparison
Chronic exercise on a treadmill vs Untrained animals (no exercise)
Design
Preclinical
Authors
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May alter rabbit cardiac electrophysiology intrinsically; leaves open translation to human arrhythmia risk or training effects.
Does chronic exercise produce intrinsic changes on automatism, conduction, and refractoriness in isolated rabbit hearts?
Chronic exercise training depresses sinus chronotropism and A-V nodal conduction, and increases ventricular refractoriness by intrinsic mechanisms independent of myocardial mass or coronary flow changes.
Such et al. (2002) studied this question.
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