Key result
Chronic physical exercise increased the ventricular functional refractory period (53 vs 42 ms) and decreased intrinsic myocardial electrophysiological heterogeneity in isolated rabbit hearts.
Why the study?
The effect of chronic exercise on myocardial electrophysiological heterogeneity and stability, and the role of cholinergic neurons in these changes, required investigation.
Does chronic exercise improve myocardial electrophysiological stability and decrease heterogeneity in isolated rabbit hearts, and what is the role of intrinsic cholinergic neurons?
Population
Isolated perfused hearts from untrained and treadmill-trained rabbits
Comparison
Trained vs untrained control rabbits before and after atropine
Design
Preclinical isolated heart study
Authors
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Does not support clinical changes; leaves open translation of exercise effects on ventricular stability to human arrhythmia models.
Does chronic exercise improve myocardial electrophysiological stability and decrease heterogeneity in isolated rabbit hearts, and what is the role of intrinsic cholinergic neurons?
Absolute Event Rate: 53% vs 42%
p-value: p=<0.05
Chronic physical training decreases intrinsic myocardial electrophysiological heterogeneity and increases stability in an isolated rabbit heart model, independent of intrinsic cholinergic neurons.
Such‐Miquel et al. (2018) studied Ventricular Fibrillation (Animal Model) (n=21). Chronic physical exercise (treadmill running) vs. Sedentary control was evaluated on Ventricular functional refractory period (FRPVF) prior to atropine (p=<0.05). Chronic physical exercise increased the ventricular functional refractory period (53 vs 42 ms) and decreased intrinsic myocardial electrophysiological heterogeneity in isolated rabbit hearts.
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