Key result
Physical training reduced intrinsic sinoatrial frequency in rats independently of parasympathetic activity, and the properties setting this frequency also influenced the maximum norepinephrine response.
Population
Rats divided into six groups
Comparison
Treadmill exercise and/or pharmacological… vs Inactive control
Design
Preclinical
Follow-up
10 weeks
Authors
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Supports non-vagal mechanisms for training-induced sinoatrial slowing in rats; leaves open human translation and clinical relevance.
Physical training reduces intrinsic sinoatrial frequency in rats through mechanisms independent of parasympathetic nervous system activity.
Hughson et al. (1977) studied this question. Physical training (treadmill exercise) and/or parasympathetic modulation (atropine/carbachol) vs. Inactive control was evaluated on Intrinsic sinoatrial frequency (ISF) and chronotropic dose-response to acetylcholine and norepinephrine. Physical training reduced intrinsic sinoatrial frequency in rats independently of parasympathetic activity, and the properties setting this frequency also influenced the maximum norepinephrine response.
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