Population
Pithed rats with hearts perfused at a constant flow or pressure with a modified Krebs-Henseleit solution…
Comparison
Electrical stimulation of sympathetic nerves at… vs Constant atrial pacing with an equivalent rate
Design
Preclinical
Follow-up
90 seconds
Authors
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Sympathetic stimulation may dissociate chronotropy from inotropy; challenges consensus on uniform effects and leaves open human translation.
In rat hearts, sympathetic stimulation causes a progressive increase in heart rate but a transient increase followed by a decrease in contractility, demonstrating a dissociation of chronotropic and inotropic responses.
Onuki et al. (1999) studied this question.
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