Why the study?
Does atenolol compared to pindolol affect fetal heart rate and maternal arterial pressure in pregnant women with pregnancy hypertension?
Does atenolol compared to pindolol affect fetal heart rate and maternal arterial pressure in pregnant women with pregnancy hypertension?
In pregnant women with hypertension, atenolol but not pindolol decreases basal fetal heart rate, though both effectively reduce maternal blood pressure.
May lower fetal heart rate with atenolol but not pindolol despite similar maternal BP reduction in hypertensive pregnancies; hypothesis-generating and requires randomized confirmation.
The effects of two different beta-adrenergic antagonists on maternal arterial pressure and fetal heart rate were studied in 8 pregnant women with pregnancy hypertension. The fetal heart rate was monitored by abdominal ECG recording under standardized conditions. Basal heart rate, long-term variability and short-term variability were calculated in a computer. Four patients received 50-100 mg atenolol once daily; the other 4 received pindolol 10 mg b.i.d. Reduction in mean arterial blood pressure was seen in both groups of patients. The basal fetal heart rate was decreased in atenolol-exposed fetuses but not in pindolol-exposed fetuses. In this preliminary study there was no apparent effect on the fetal heart rate variability.
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Ingemarsson et al. (1984) studied this question.
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