September 4, 2009Annals of Neurology
Muscle magnetic resonance imaging involvement in muscular dystrophies with rigidity of the spine
Why the study?
Does visual analysis of muscle MRI scans identify specific patterns of muscle involvement in patients with muscular dystrophies with rigidity of the spine?
Population
108 patients, including 83 with muscle disorders characterized by rigidity of the spine secondary to…
Comparison
Visual analysis of muscle magnetic resonance… vs Scans of 25 patients affected by other myopathies
Design
Cohort
Authors
Discussion
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Implication
Muscle MRI patterns may aid differential diagnosis in rigid-spine dystrophies; leaves open prospective validation against genetic testing.
Structured PICO
Does visual analysis of muscle MRI scans identify specific patterns of muscle involvement in patients with muscular dystrophies with rigidity of the spine?
P
Population
108 patients, including 83 with muscle disorders characterized by rigidity of the spine secondary to mutations in 4 different genes (SEPN1, Col6A1/2/3, LMNA, CAPN3) and 25 patients with other myopathies as a control group.
I
Intervention
Visual analysis of muscle magnetic resonance imaging (MRI) scans
C
Comparator
Scans of 25 patients affected by other myopathies (control group)
O
Outcome
Identification of specific patterns of muscle involvement consistent with genetic diagnosissurrogate
Muscle MRI can be used as an additional tool in the differential diagnosis of muscle disorders with prominent spinal rigidity.
Cite This Study
Mercuri et al. (2009) studied this question.