Key result
Muscle MRI in facioscapulohumeral muscular dystrophy revealed combined abdominal and hamstring involvement in 67% of patients, and early lesions in undetected muscles in 69% of patients <45 years.
Why the study?
What is the pattern and extent of muscle involvement on MRI in patients with facioscapulohumeral muscular dystrophy?
Population
269 symptomatic individuals with facioscapulohumeral muscular dystrophy and 19 nonpenetrant gene carriers
Design
Cross-sectional
Authors
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May aid subclinical FSHD detection; hypothesis-generating for MRI as trial biomarker pending validation.
Cross-Sectional (n=288)
What is the pattern and extent of muscle involvement on MRI in patients with facioscapulohumeral muscular dystrophy?
Muscle MRI reveals specific patterns of muscle involvement in facioscapulohumeral muscular dystrophy, correlating with clinical severity and potentially serving as a useful biomarker for clinical trials.
Tasca et al. (2016) conducted a cross-sectional in Facioscapulohumeral muscular dystrophy (n=288). Magnetic resonance imaging (MRI) was evaluated on Type and extent of muscle involvement on MRI. Muscle MRI in facioscapulohumeral muscular dystrophy revealed combined abdominal and hamstring involvement in 67% of patients, and early lesions in undetected muscles in 69% of patients <45 years.
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