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August 25, 2017PLoS ONEOpen Access

The relative rate of MPItotal change was 2.3% (0.5-4.3)/year and was significantly higher than the corresponding rates measured for MRCS 0% (0-1.7)/year and MFMtotal 0% (0-2.0)/year (p = 0.000).

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Why the study?

Does quantitative MRI using mean pixel intensity (MPI) detect subclinical disease progression in patients with Facioscapulohumeral muscular dystrophy (FSHD) compared to clinical assessment tools?

Population

35 FSHD1 patients (17 females)

Design

Cohort

Follow-up

1 to 2 years

Authors

FFFarzad FatehiESEmmanuelle Salort‐CampanaATArnaud Le Troter

Discussion

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Overview

Quantitative MRI using the MPItotal index can detect subclinical disease progression in FSHD over a short period, serving as a reliable biomarker when clinical scales show no significant change.

Structured PICO

Does quantitative MRI using mean pixel intensity (MPI) detect subclinical disease progression in patients with Facioscapulohumeral muscular dystrophy (FSHD) compared to clinical assessment tools?

P
Population
35 FSHD1 patients (17 females)
I
Intervention
Quantitative MRI using mean pixel intensity (MPI) calculated from T1 weighted images
O
Outcome
Time-dependent changes in thigh muscles using quantitative MRI (MPItotal) and relationships with clinical findingssurrogate

Quantitative MRI using the MPItotal index can detect subclinical disease progression in FSHD over a short period, serving as a reliable biomarker when clinical scales show no significant change.

Cite This Study

Fatehi et al. (2017) studied this question.

synapsesocial.com/papers/6a8692e7adfdeade3289c3cehttps://doi.org/10.1371/journal.pone.0183825
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Also Consider

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