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July 16, 2015PLoS ONEOpen Access

The intramuscular fat fraction measured using qMRI in the thighs was significantly higher in patients (21.9 ± 20.4%) than in volunteers (3.6 ± 2.8%) (p<0.001) and correlated with the CSS scale (p ≤ 0.01).

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Why the study?

Does quantitative MRI accurately measure intramuscular fat fraction and correlate with clinical severity in patients with FSHD1?

Population

35 patients with Facioscapulohumeral muscular dystrophy type 1 and 22 healthy volunteers. Patient group…

Comparison

Quantitative MRI combined with a dedicated… vs Standard T1-weighted four-point visual scale and…

Design

Cross-sectional

Authors

ÉLÉmilie Lareau-TrudelATArnaud Le TroterBGBadih Ghattas

Discussion

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Overview

qMRI fat fraction may quantify FSHD1 burden; leaves open prospective validation for monitoring or trials.

Structured PICO

Does quantitative MRI accurately measure intramuscular fat fraction and correlate with clinical severity in patients with FSHD1?

P
Population
35 patients with Facioscapulohumeral muscular dystrophy type 1 (FSHD1) and 22 healthy volunteers. Patient group: mean age 45.9, 19 women (54%).
I
Intervention
Quantitative MRI (qMRI) combined with a dedicated automated segmentation method
C
Comparator
Standard T1-weighted four-point visual scale (visual score) and healthy volunteers
O
Outcome
Intramuscular fat fraction in the thighssurrogate

Quantitative MRI provides a sensitive measurement of intramuscular fat fraction that correlates with clinical severity in FSHD1 patients, overcoming the ceiling effect of visual scoring.

Cite This Study

Lareau-Trudel et al. (2015) studied this question.

synapsesocial.com/papers/6a88f6d8e49c960f581fee6ehttps://doi.org/10.1371/journal.pone.0132717
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adding quantitative muscle MRI to the FSHD clinical trial toolbox2017 · 98 citations
  2. 2Natural history of facioscapulohumeral muscular dystrophy evaluated by multiparametric quantitative MRI: a prospective cohort study2025 · 8 citations
  3. 3Comparison of quantitative muscle ultrasound and whole-body muscle MRI in facioscapulohumeral muscular dystrophy type 1 patients2023 · 10 citations
  4. 4Distinct Disease Phases in Muscles of Facioscapulohumeral Dystrophy Patients Identified by MR Detected Fat Infiltration2014 · 149 citations
  5. 5Whole‐body magnetic resonance imaging evaluation of facioscapulohumeral muscular dystrophy2015 · 91 citations