December 22, 2008Acta Neurologica Scandinavica

Whole-body MRI demonstrated widespread muscular pathology in symptomatic patients, including involvement of the anterior and posterior thigh compartments, posterior lower legs, glutei, erector spinae, and shoulder girdle muscles, and detected subclinical muscle pathology.

View Full Paper

Ask AI

Bookmark

Why the study?

Does whole-body 3.0-T MRI detect subclinical muscle pathology and correlate with clinical manifestations in patients with primary dysferlinopathies?

Population

6 German patients with primary dysferlinopathies defined by absence of dysferlin expression in muscle

Design

Case_series

Authors

KKK KesperUniversity Hospital Bonn CKCornelia KornblumUniversity of Bonn JRJens ReimannUniversity Hospital Bonn

Discussion

Member takes

Overview

May support MRI characterization of dysferlinopathies; case-report evidence leaves open routine diagnostic adoption.

Structured PICO

Does whole-body 3.0-T MRI detect subclinical muscle pathology and correlate with clinical manifestations in patients with primary dysferlinopathies?

Population

6 German patients with primary dysferlinopathies defined by absence of dysferlin expression in muscle (distal Miyoshi myopathy [MM], n = 3; limb girdle muscular dystrophy type 2B [LGMD2B], n = 2; hyperCKemia without clinical symptoms, n = 1)

Intervention

Whole-body 3.0-T magnetic resonance imaging (MRI)

Outcome

Correlations between clinical manifestations and muscle imaging changes (pattern of skeletal muscle involvement)surrogate

Whole-body 3.0-T MRI is a useful non-invasive tool for detecting subclinical muscle pathology and differentiating primary dysferlinopathies from other muscular dystrophies.

Cite This Study

Kesper et al. (2008) studied this question.

synapsesocial.com/papers/6a910b5ec39ca0eda18309bd https://doi.org/10.1111/j.1600-0404.2008.01129.x

View Full Paper

Ask AI

Bookmark

December 22, 2008Acta Neurologica Scandinavica

Whole-body MRI demonstrated widespread muscular pathology in symptomatic patients, including involvement of the anterior and posterior thigh compartments, posterior lower legs, glutei, erector spinae, and shoulder girdle muscles, and detected subclinical muscle pathology.

View Full Paper

Ask AI

Bookmark

Why the study?

Does whole-body 3.0-T MRI detect subclinical muscle pathology and correlate with clinical manifestations in patients with primary dysferlinopathies?

Population

6 German patients with primary dysferlinopathies defined by absence of dysferlin expression in muscle

Design

Case_series

Authors

KKK KesperUniversity Hospital Bonn CKCornelia KornblumUniversity of Bonn JRJens ReimannUniversity Hospital Bonn

Discussion

Member takes

Overview

May support MRI characterization of dysferlinopathies; case-report evidence leaves open routine diagnostic adoption.

Structured PICO

Does whole-body 3.0-T MRI detect subclinical muscle pathology and correlate with clinical manifestations in patients with primary dysferlinopathies?

Population

Intervention

Whole-body 3.0-T magnetic resonance imaging (MRI)

Outcome

Correlations between clinical manifestations and muscle imaging changes (pattern of skeletal muscle involvement)surrogate

Whole-body 3.0-T MRI is a useful non-invasive tool for detecting subclinical muscle pathology and differentiating primary dysferlinopathies from other muscular dystrophies.

Cite This Study

Kesper et al. (2008) studied this question.

synapsesocial.com/papers/6a910b5ec39ca0eda18309bd https://doi.org/10.1111/j.1600-0404.2008.01129.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark