What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Dysferlinopathy (n=40). Intervention: Muscle MRI. Primary outcome: Pattern and extent of fatty infiltration and edema.

What does this research mean for the field?

Muscle involvement patterns on MRI in dysferlinopathy differ significantly by clinical phenotype, and specific patterns of muscle affliction correlate directly with characteristic gait abnormalities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 2025Annals of Indian Academy of NeurologyOpen Access

Muscle MRI Pattern in Dysferlinopathy and its Correlation with Dysferlin Gait

View Full Paper

Ask AI

Bookmark

Key result

Muscle MRI in dysferlinopathy reveals phenotype-specific patterns, with worse flexor hallucis longus involvement in proximodistal variants.

n=40

Why the study?

Magnetic resonance imaging in dysferlinopathy consistently shows a particular pattern of affliction, prompting this study to evaluate lower-limb muscle MRI characteristics in limb girdle muscular dystrophy-R2 phenotypes and correlate them with gait pattern.

Does muscle MRI pattern correlate with phenotype and gait in patients with dysferlinopathy?

Design

Cross-sectional correlation study

Authors

TCTanushree ChawlaMedanta The Medicity DBDipti BaskarNational Institute of Mental Health and Neurosciences KPKiran PolavarapuUniversity of Ottawa

Discussion

Member takes

Implication

Supports phenotype-specific MRI patterns in dysferlinopathy; leaves open gait correlation and clinical utility.

Study Design

Type

Cross-Sectional (n=40)

Structured PICO

Does muscle MRI pattern correlate with phenotype and gait in patients with dysferlinopathy?

Population

40 patients with genetically and/or biopsy-proven dysferlinopathy (33.3% female) evaluated with lower limb muscle MRI to correlate muscle characteristics with gait patterns.

Exposure

Muscle MRI of the lower limbs

Outcome

Pattern and extent of fatty infiltration and edema, and correlation with demographics, duration of illness, Muscular Dystrophy Functional Rating Scale (MDFRS), genotype, and gait patternsurrogate

Muscle MRI reveals distinct patterns of involvement in different dysferlinopathy phenotypes, correlating with clinical severity and gait patterns.

Cite This Study

Chawla et al. (2025) conducted a cross-sectional in Dysferlinopathy (n=40). Muscle MRI was evaluated on Pattern and extent of fatty infiltration and edema. Muscle MRI in dysferlinopathy revealed phenotype-specific patterns of muscle involvement, with the proximodistal phenotype showing more severe involvement of the flexor hallucis longus.

synapsesocial.com/papers/6a1eb710544bdf605faf34a3 https://doi.org/10.4103/aian.aian_987_24

View Full Paper

Ask AI

Bookmark

Muscle MRI Pattern in Dysferlinopathy and its Correlation with Dysferlin Gait

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Muscle MRI Pattern in Dysferlinopathy and its Correlation with Dysferlin Gait

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider