Why the study?
Closed-loop deep brain stimulation offers effective treatment for intractable neurological disorders, but faced challenges requiring a high-precision device.
A novel closed-loop DBS device demonstrates high precision and stability in bench-top and animal experiments, showing potential for long-term neuromodulation therapies.
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Hypothesis-generating for custom closed-loop DBS hardware; leaves open human translation and trials.
Closed-loop deep brain stimulation (DBS) is an emerging technology in the field of neuromodulation, which can provide effective treatment methods for intractable neurological disorders. To address the faced challenges, this article presents a high-precision closed-loop DBS device based on a custom-designed neuromodulation integrated circuit (CNIC) fabricated in a 180-nm bipolar-CMOS-DMOS (BCD) process. Also, three new techniques have been developed to optimize system performance. First, to improve system stability, a frequency shaping & quick blanking amplifier (FSQBA)-based analog front-end is proposed to extend system dynamic range (DR). Second, both stimulation artifacts (SAs) suppression scheme and closed-loop control algorithm are developed to achieve real simultaneous recording and stimulation. Third, a redundant-crossfire (RXF) technique is designed to enhance current precision without consuming much extra area. Bench-top measurements show that the designed system features a wide DR of 112 dB, a short saturation recovery time of100~μs, and a high stimulation current resolution of 13.1-bit. Besides, animal experiments demonstrate that the designed system is highly suitable for long-term implantation applications, thus providing accurate and reliable closed-loop control for neuromodulation therapies.
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Su et al. (2025) studied this question.
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