Cardiac troponin assays: a review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarction
Why the study?
What are the performance characteristics of quantitative point-of-care cardiac troponin devices in diagnosing myocardial infarction?
Population
Patients with ischemia/chest pain evaluated for myocardial infarction
Design
Review
Authors
Discussion
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Member takes
Implication
Select POC cTn devices may aid rapid MI diagnosis; leaves open prospective validation against central-lab assays.
Structured PICO
What are the performance characteristics of quantitative point-of-care cardiac troponin devices in diagnosing myocardial infarction?
P
Population
Patients with ischemia/chest pain evaluated for myocardial infarction
I
Intervention
Nine quantitative point-of-care (POC) devices measuring cardiac troponin (cTnI and cTnT)
O
Outcome
Clinical sensitivity and specificity, and analytical imprecisionsurrogate
Point-of-care cardiac troponin devices with a coefficient of variation ≤20% at the 99th percentile upper reference limit can provide clinically acceptable findings to assist in the rapid diagnosis of myocardial infarction.
Cite This Study
Amundson et al. (2014) studied this question.