January 1, 1988Clinical and Experimental Hypertension
Enalapril and Atenolol in Essential Hypertension: Attenuation of Hypotensive Effects in Combination
Why the study?
Does the combination of enalapril and atenolol reduce blood pressure compared to either agent alone or placebo in patients with essential hypertension?
Population
16 patients with essential hypertension
Comparison
Enalapril 20 mg once daily, atenolol 50 mg once… vs Placebo administered for 4 weeks
Design
RCT, allocation of treatment order by randomised Latin squares, double-blind
Follow-up
4 weeks per treatment phase
Authors
Discussion
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Implication
Combination offers greater BP reduction than monotherapy in essential hypertension; extends evidence on subadditive ACEI-beta blocker effects.
Structured PICO
Does the combination of enalapril and atenolol reduce blood pressure compared to either agent alone or placebo in patients with essential hypertension?
P
Population
16 patients with essential hypertension
I
Intervention
Enalapril 20 mg once daily, atenolol 50 mg once daily, or their combination, each administered for 4 weeks
C
Comparator
Placebo administered for 4 weeks
O
Outcome
Supine and standing blood pressuresurrogate
The combination of enalapril and atenolol provides additional blood pressure reduction compared to monotherapy, but the effects are less than fully additive.
Cite This Study
Wing et al. (1988) studied this question.