Why the study?
Does enalapril combined with a very low dose of hydrochlorothiazide reduce blood pressure more effectively than atenolol in patients with mild-to-moderate hypertension?
Population
n=374 patients with mild-to-moderate hypertension
Comparison
Enalapril/hydrochlorothiazide for 12 weeks after… vs Atenolol for 12 weeks after a 4-week placebo…
Design
RCT, Randomized, parallel, Triple-blind
Follow-up
12 weeks
Authors
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Supports preferring enalapril/HCTZ over atenolol for systolic BP control in mild-to-moderate hypertension; extends RCT evidence for low-dose ACEI-diuretic combinations.
Does enalapril combined with a very low dose of hydrochlorothiazide reduce blood pressure more effectively than atenolol in patients with mild-to-moderate hypertension?
The combination of enalapril and very low-dose hydrochlorothiazide is more effective at reducing sitting systolic blood pressure than atenolol in patients with mild-to-moderate hypertension, with comparable tolerability.
Ingrid Os (1997) studied this question.
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