Key result
Enalapril produced similar rates of significant blood pressure reduction compared to hydrochlorothiazide (42.1% vs 52.6%; p=ns) in elderly males with mild to moderate hypertension.
Why the study?
Does enalapril reduce blood pressure compared to hydrochlorothiazide in elderly males with mild to moderate hypertension?
Population
38 elderly males (aged ≥65 years) with mild to moderate hypertension.
Comparison
Enalapril 10-20 mg/d for two to four weeks. vs Hydrochlorothiazide 12.5-25 mg/d for two to four…
Design
RCT, randomized, double-blind
Follow-up
two to four weeks
Authors
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Enalapril achieves BP control as monotherapy in some elderly hypertensives; challenges low-renin rationale discouraging ACEI and supports targeted trials.
RCT (n=38)
Double-blind
randomized
Does enalapril reduce blood pressure compared to hydrochlorothiazide in elderly males with mild to moderate hypertension?
Absolute Event Rate: 42.1% vs 52.6%
p-value: p=ns
Enalapril provides comparable blood pressure reduction to hydrochlorothiazide in elderly males with mild to moderate hypertension, suggesting ACE inhibitors can be effective monotherapy in this population.
Gums et al. (1988) conducted an RCT in Mild to moderate hypertension (n=38). Enalapril vs. Hydrochlorothiazide (HCTZ) 12.5-25 mg/d was evaluated on Significant reductions in systolic and diastolic BP in seated and standing positions (p=ns). Enalapril produced similar rates of significant blood pressure reduction compared to hydrochlorothiazide (42.1% vs 52.6%; p=ns) in elderly males with mild to moderate hypertension.
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