Why the study?
Does enalapril compared to hydrochlorothiazide improve blood pressure reduction in elderly patients with hypertension?
Population
174 elderly patients with diastolic blood pressures of 90-120 mm Hg or isolated systolic hypertension, 68%…
Comparison
Enalapril 10 mg once daily vs Hydrochlorothiazide 12.5 mg once daily
Design
RCT, randomized, double blind
Follow-up
end of the study
Authors
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Both agents lower BP similarly in elderly hypertensives; confirms comparable efficacy of ACE inhibitor versus thiazide.
Does enalapril compared to hydrochlorothiazide improve blood pressure reduction in elderly patients with hypertension?
Enalapril and hydrochlorothiazide are similarly effective in reducing blood pressure in elderly patients with essential or isolated systolic hypertension.
Шапиро et al. (1987) studied this question.
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