Why the study?
Does the presence of 3 or more pituitary hormone deficiencies or serum IGF-I < 84 microg/liter accurately diagnose adult GH deficiency without the need for GH stimulation testing?
Population
817 adult patients enrolled in the U.S. Hypopituitary Control and Complications Study evaluated for adult GH…
Comparison
Diagnostic criteria of either 3 or 4 additional… vs GH stimulation testing
Design
Cohort
Authors
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May support avoiding GH stimulation testing in suspected GHD with 3-4 PHDs or IGF-I <84 μg/L; leaves open prospective validation before practice change.
Does the presence of 3 or more pituitary hormone deficiencies or serum IGF-I < 84 microg/liter accurately diagnose adult GH deficiency without the need for GH stimulation testing?
Patients with suspected adult GH deficiency and either 3-4 additional pituitary hormone deficiencies or serum IGF-I < 84 microg/L can be diagnosed without invasive GH stimulation testing.
Hartman et al. (2002) studied this question.
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