Nitroglycerin alters arterial pressure waveforms through changes in arterial distensibility and reflected wave patterns, which may vary based on the degree of atherosclerosis.
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May affect waveform interpretation during catheterization; hypothesis-generating for atherosclerosis-dependent effects on distensibility.
Nitroglycerin has dependable, short-lived veno- and arterial vasodilatory effects ameliorating ischemia through both preload reduction and coronary vasodilation. Nitroglycerin should be used prior to left ventriculography in patients with elevated left ventricular end-diastolic pressure. The arterial pressure waveform alteration of nitroglycerin can be explained on the basis of changes in arterial distensibility and reflected wave patterns and may vary considerably among individuals with different degrees of atherosclerosis.
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Kern et al. (1992) studied this question.
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