What question did this study set out to answer?

This analysis explores the baseline characteristics associated with difficult-to-treat rheumatoid arthritis (D2T-RA) using four varying definitions.

Baseline Predictors of Difficult-To-Treat Rheumatoid Arthritis Across Adapted Definitions: Insights from the OBRI-RA Registry

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Randomized trial evaluates predictors of difficult-to-treat rheumatoid arthritis, highlighting clinical insights.

This analysis explores the baseline characteristics associated with difficult-to-treat rheumatoid arthritis (D2T-RA) using four varying definitions.
Data from the Ontario Best Practices Research Initiative (OBRI) registry of rheumatoid arthritis patients was utilized.
Multivariable logistic regression analyses were performed for each of the four adapted definitions of D2T-RA.
Candidate predictors included demographic, clinical, serologic, and treatment-related variables identified a priori.
The analysis included 507 patients with a mean age of 56.9 years and 80.3% female.
Female sex independently predicted D2T-RA with higher odds ratios under Definitions 2 (OR 2.46) and 3 (OR 3.42).
Higher HAQ-pain scores consistently correlated with D2T-RA across inclusive definitions (OR 1.60-2.00, p < 0.05).

Attar et al. (2026) studied this question.

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