Population
Embryonic mouse hearts and isolated ventricular myocytes at 9.5 days postcoitum (dpc) and 18 dpc
Comparison
Isoproterenol, Forskolin, and Propranolol vs Baseline measurements prior to drug application
Design
Preclinical
Authors
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Beta-adrenergic modulation of L-type Ca currents occurs early in mouse embryogenesis; extends developmental timeline but leaves open human relevance.
This study demonstrates that L-type Ca2+-channel currents are modulated by beta-adrenergic receptors in the embryonic mouse heart as early as 9.5 days postcoitum.
Liu et al. (1999) studied this question.
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