Population
Patients with heart failure with preserved ejection fraction (HFpEF)
Design
Review
Authors
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Supports phenotype-targeted HFpEF trials; leaves open whether such strategies improve outcomes over universal approaches.
HFpEF is a highly heterogeneous syndrome that likely requires targeted therapies tailored to specific pathophysiological phenotypes rather than a universal treatment strategy.
Tannenbaum et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: