Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas

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Population

34 angiosarcomas

Design

Cohort

Authors

Discussion

Low VEGFR-2 expression may identify higher-risk angiosarcoma; hypothesis-generating for biomarker validation, should not yet change practice.

Population

34 angiosarcomas

Intervention

Immunohistochemical expression analysis of VEGF-A, VEGF-C, VEGFR-1, VEGFR-2, VEGFR-3

Outcome

Prognosis associated with VEGFR expressionsurrogate

Low or no VEGFR-2 expression in angiosarcomas is associated with a significantly unfavorable prognosis.

Itakura et al. (2007) studied this question.

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Low VEGFR-2 expression may identify higher-risk angiosarcoma; hypothesis-generating for biomarker validation, should not yet change practice.