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June 15, 1995CancerOpen Access

Use of immunohistochemical procedures in diagnosing angiosarcoma. Evaluation of 98 cases

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Population

98 cases of autopsy-proven angiosarcoma diagnosed during 1974-1990 from a survey of 178 Japanese hospitals

Design

Case_series

Authors

MOMasahiko OhsawaOsaka Metropolitan UniversityNNNorifumi NakaUniversity of the WitwatersrandYTYasuhiko TomitaThe University of Osaka

Discussion

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Implication

Endothelial markers may aid angiosarcoma diagnosis in ambiguous patterns; leaves open validation in larger prospective series.

Structured PICO

P
Population
98 cases of autopsy-proven angiosarcoma diagnosed during 1974-1990 from a survey of 178 Japanese hospitals
I
Intervention
Immunohistochemical staining with antibodies against Factor VIII-related antigen (FVIIIRA), Ulex europaeus lectin type 1 (UEA-1), CD31, vascular endothelial growth factor (VEGF), epithelial membrane antigen, cytokeratin, and melanoma cell antigen (HMB45)
O
Outcome
Reactivity of angiosarcoma cells to immunohistochemical markers in vasoformative and non- or poorly vasoformative areassurrogate

The combined use of endothelial cell markers FVIIIRA, UEA-1, and CD31 is useful for diagnosing angiosarcoma, particularly in cases with non- or poorly vasoformative patterns.

Cite This Study

Ohsawa et al. (1995) studied this question.

synapsesocial.com/papers/6a71d53035aa2c282ce2f472https://doi.org/10.1002/1097-0142(19950615)75:12<2867::aid-cncr2820751212>3.0.co;2-8
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Also Consider

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  1. 1Epithelioid Angiosarcoma of Deep Soft Tissue1991 · 283 citations
  2. 2Angiosarcoma of the heart: pericardial fluid cytology1990 · 33 citations
  3. 3Angiosarcoma in Japan. A review of 99 cases1995 · 217 citations
  4. 4Immunohistochemical Identification of Factor VIII-Related Antigen in Endothelial Cells of Cutaneous Lesions of Alleged Vascular Nature1981 · 240 citations
  5. 5Human Vascular Permeability Factor1989 · 287 citations