January 1, 1986Clinical Pharmacology & Therapeutics
Effects of combination therapy with captopril and nifedipine in severe or resistant hypertension
Why the study?
Does combination therapy with captopril and nifedipine reduce blood pressure in patients with severe or resistant hypertension?
Population
10 patients with severe or resistant hypertension
Comparison
Captopril monotherapy for 4 weeks followed by… vs Baseline (pre-treatment) and captopril monotherapy
Design
Case_series
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
May support additive BP reduction with captopril plus nifedipine in resistant hypertension; hypothesis-generating case report requiring controlled trials.
Structured PICO
Does combination therapy with captopril and nifedipine reduce blood pressure in patients with severe or resistant hypertension?
P
Population
10 patients with severe or resistant hypertension
I
Intervention
Captopril monotherapy for 4 weeks followed by combination therapy with captopril and nifedipine for 8 weeks
C
Comparator
Baseline (pre-treatment) and captopril monotherapy
O
Outcome
Blood pressuresurrogate
Combination therapy with captopril and nifedipine effectively reduces blood pressure in patients with severe or resistant hypertension, though frequent dosing intervals may be necessary for 24-hour control.
Cite This Study
White et al. (1986) studied this question.