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December 1, 1987Journal of Hypertension

Captopril and Nifedipine Interactions in the Treatment of Essential Hypertensives: A Crossover Study

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Why the study?

Does the combination of captopril and nifedipine improve blood pressure reduction and tolerability compared to monotherapy or placebo in patients with uncomplicated essential hypertension?

Population

n=32 uncomplicated essential hypertensives. Key inclusion: diastolic blood pressure >105 and <120mmHg at the…

Comparison

Captopril, nifedipine, and captopril plus… vs Corresponding placebo given for 1 month.

Design

RCT, randomized crossover design, double-blind

Follow-up

1 month per treatment period

Authors

ASAntonio SalvettiPIPier F. InnocentiMLManrico lardella

Discussion

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Overview

Supports ACE inhibitor–CCB combination for superior BP control in essential hypertension; confirms additive effects over monotherapy in RCTs.

Structured PICO

Does the combination of captopril and nifedipine improve blood pressure reduction and tolerability compared to monotherapy or placebo in patients with uncomplicated essential hypertension?

P
Population
n=32 uncomplicated essential hypertensives. Key inclusion: diastolic blood pressure >105 and <120mmHg at the end of a 1-month placebo washout period.
I
Intervention
Captopril (50 mg twice daily), nifedipine (20 mg twice daily), and captopril plus nifedipine at the same doses, each given for 1 month in a crossover design.
C
Comparator
Corresponding placebo given for 1 month.
O
Outcome
Mean blood pressuresurrogate

The combination of an ACE inhibitor (captopril) and a calcium channel blocker (nifedipine) provides additive blood pressure reduction while potentially mitigating CCB-induced ankle edema.

Cite This Study

Salvetti et al. (1987) studied this question.

synapsesocial.com/papers/6a71b68ef44fa9f079df712fhttps://doi.org/10.1097/00004872-198712004-00023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic and humoral interactions between captopril and nifedipine.1983 · 36 citations
  2. 2Effects of combination therapy with captopril and nifedipine in severe or resistant hypertension1986 · 46 citations
  3. 3Calcium-channel blockade with nifedipine and angiotensin converting-enzyme inhibition with captopril in the therapy of patients with severe primary hypertension.1984 · 120 citations
  4. 4Comparison of Nifedipine and captopril as Third‐Line Agents in Hypertensive Patients Uncontrolled With Beta‐Blocker and Diuretic Therapy1987 · 5 citations
  5. 5Plasma Renin Activity and Norepinephrine as Predictors for Antihypertensive Effects of Nifedipine and Captopril1991 · 13 citations