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December 27, 1969BMJOpen Access

Intravenous glucose tolerance, insulin, glucose, and free fatty acid levels after myocardial infarction

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Why the study?

Does acute myocardial infarction alter glucose tolerance, insulin secretion, and free fatty acid levels compared to the convalescent phase?

Population

12 patients with myocardial infarction (including patients with cardiogenic shock)

Comparison

Intravenous glucose tolerance test performed… vs Repeated intravenous glucose tolerance test two…

Design

Cohort

Follow-up

two to four weeks

Authors

SAS.P. AllisonBeth Israel Deaconess Medical CenterMCMichael J. ChamberlainUniversity of GeorgiaPHPamela S. HintonUniversity of Missouri

Discussion

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Implication

Should not yet change glucose management post-AMI; extends metabolic observations but remains hypothesis-generating pending trials.

Structured PICO

Does acute myocardial infarction alter glucose tolerance, insulin secretion, and free fatty acid levels compared to the convalescent phase?

P
Population
12 patients with myocardial infarction (including patients with cardiogenic shock)
I
Intervention
Intravenous glucose tolerance test performed within 15 hours of myocardial infarction
C
Comparator
Repeated intravenous glucose tolerance test two to four weeks later
O
Outcome
Insulin secretion, glucose tolerance, and free fatty acid levelssurrogate

Acute myocardial infarction induces significant transient metabolic derangements, including impaired insulin secretion and elevated free fatty acids, which are exacerbated by cardiogenic shock.

Cite This Study

Allison et al. (1969) studied this question.

synapsesocial.com/papers/6a70468e6ceb2bbd16dfd890https://doi.org/10.1136/bmj.4.5686.776
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyperglycemia in Coronary Thrombosis1952 · 31 citations
  2. 2The colorimetric micro-determination of long-chain fatty acids1963 · 977 citations