Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2017SA HeartOpen Access

Using biomarkers and early prophylactic treatment to prevent cardiotoxicity in cancer patients on chemotherapy

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does early biomarker-guided detection and prophylactic treatment with ACE inhibitors prevent LVEF reduction and cardiac events in cancer patients on chemotherapy?

Population

Cancer patients on chemotherapy at risk of cardiotoxicity

Comparison

Measurement of cardio-specific biomarkers for… vs Current standard for monitoring cardiac function

Design

Review

Authors

GBGiulia BacchianiDCDaniela Cardinale

Discussion

Loading...

Member takes

Overview

Biomarker monitoring may enable earlier prophylaxis before functional decline; leaves open optimal thresholds for routine practice.

Structured PICO

Does early biomarker-guided detection and prophylactic treatment with ACE inhibitors prevent LVEF reduction and cardiac events in cancer patients on chemotherapy?

P
Population
Cancer patients on chemotherapy at risk of cardiotoxicity
I
Intervention
Measurement of cardio-specific biomarkers (Troponin I) for early identification of subclinical cardiotoxicity and subsequent prophylactic treatment with angiotensin-converting enzyme (ACE) inhibitors, possibly in combination with beta-blocking agents
C
Comparator
Current standard for monitoring cardiac function (detecting functional impairment after it has already occurred)
O
Outcome
Prevention of left ventricular ejection fraction (LVEF) reduction and cardiac events

Biomarker-guided early detection of cardiotoxicity and prompt initiation of ACE inhibitors may prevent irreversible left ventricular dysfunction in cancer patients undergoing chemotherapy.

Cite This Study

Bacchiani et al. (2017) studied this question.

synapsesocial.com/papers/6a704995439bab0cabc31a2bhttps://doi.org/10.24170/9-4-1828
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Using biomarkers to predict and to prevent cardiotoxicity of cancer therapy2017 · 95 citations
  2. 2Using Cardiac Biomarkers and Treating Cardiotoxicity in Cancer2012 · 33 citations
  3. 3Role of biomarkers in cardioncology2011 · 44 citations
  4. 4Oncologic therapies associated with cardiac toxicities: how to minimize the risks2019 · 8 citations
  5. 5Roadmap for biomarkers of cancer therapy cardiotoxicity2015 · 73 citations