Key result
Adipose-derived CD34+/CD31- cells increase blood flow and capillary density in ischemic hindlimbs.
Why the study?
The presence and characteristics of stem/progenitor cells in the stroma-vascular fraction of human adipose tissue and their potential to improve vasculogenesis were not fully characterized.
Does intravenous injection of CD34+/CD31- cells from human adipose tissue improve neovascularization in a mouse ischemic hindlimb model?
Population
Human adipose tissue from subcutaneous and visceral depots and mouse ischemic hindlimb model
Comparison
Intravenous injection of CD34+/CD31- cells vs no injection
Design
Preclinical experimental study with cell sorting and mouse model
Authors
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Supports adipose progenitor therapy for ischemia; leaves open clinical translation from this murine model.
Does intravenous injection of CD34+/CD31- cells from human adipose tissue improve neovascularization in a mouse ischemic hindlimb model?
Human adipose tissue contains CD34+/CD31- cells that exhibit characteristics of endothelial progenitor cells and can improve postnatal neovascularization in an ischemic hindlimb model.
Miranville et al. (2004) studied Ischemic hindlimb. CD34+/CD31- cells from human adipose tissue was evaluated on Blood flow and capillary density. Intravenous injection of human adipose tissue-derived CD34+/CD31- cells increased blood flow and capillary density in a mouse ischemic hindlimb model.
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