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March 1, 2003European Journal of Clinical Investigation

Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations

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Why the study?

Does the Glu298Asp polymorphism of endothelial nitric oxide synthase associate with coronary artery disease, carotid atherosclerosis, or forearm vascular reactivity in Austrian populations?

Population

Two independent Austrian populations: a case-control study including 240 patients with angiographically…

Comparison

Homozygous Asp/Asp genotype of the Glu298Asp… vs Glu/Glu and Glu/Asp genotypes of the Glu298Asp…

Design

Case-control

Authors

ISI. SchmoelzerUniversity of GrazWRWilfried RennerMedical University of GrazBPBernhard PaulweberParacelsus Medical University

Discussion

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Overview

No association in this Austrian cohort; leaves open Glu298Asp relevance in other populations or with refined endpoints.

Structured PICO

Does the Glu298Asp polymorphism of endothelial nitric oxide synthase associate with coronary artery disease, carotid atherosclerosis, or forearm vascular reactivity in Austrian populations?

P
Population
Two independent Austrian populations: a case-control study including 240 patients with angiographically verified coronary artery disease (CAD) and 248 controls, and a cross-sectional epidemiological study including 932 subjects.
I
Intervention
Homozygous Asp/Asp genotype of the Glu298Asp polymorphism of endothelial nitric oxide synthase
C
Comparator
Glu/Glu and Glu/Asp genotypes of the Glu298Asp polymorphism
O
Outcome
Association with coronary artery disease (CAD), age of onset of CAD, myocardial infarction, carotid intima-media thickness (IMT), morphological plaque burden, and forearm vascular reactivitysurrogate

The Glu298Asp polymorphism of endothelial nitric oxide synthase is not associated with coronary or carotid atherosclerosis or forearm vascular reactivity in Austrian populations.

Cite This Study

Schmoelzer et al. (2003) studied this question.

synapsesocial.com/papers/6a704ecf75498292b709b71fhttps://doi.org/10.1046/j.1365-2362.2003.01108.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension1998 · 525 citations
  2. 2The Role of Carotid Arterial Intima-Media Thickness in Predicting Clinical Coronary Events1998 · 1,224 citations
  3. 3Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase2000 · 74 citations
  4. 4Endothelial Dysfunction: Does It Matter? Is It Reversible?1997 · 686 citations
  5. 5Comparison of fatal coronary heart disease occurrence based on population surveys in Japan and the USA2000 · 84 citations