What question did this study set out to answer?

To evaluate whether hepatitis C virus–specific CD8+ T lymphocyte responses correlate with viral clearance or progression to chronic disease in acute hepatitis C.

May 1, 2000The Journal of Infectious DiseasesOpen Access

Association of Hepatitis C Virus–Specific CD8+T Cells with Viral Clearance in Acute Hepatitis C

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Authors

NGNorbert H. GrünerLMU Klinikum TGTilman GerlachUniversity of St.Gallen MJMaria–Christina JungUniversity of Bonn

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Implication

Cohort study reveals an association between early CD8+ T cell responses and viral clearance in acute hepatitis C, suggesting cellular immunity drives infection resolution.

Key Points

To evaluate whether hepatitis C virus–specific CD8+ T lymphocyte responses correlate with viral clearance or progression to chronic disease in acute hepatitis C.
Evaluated 18 patients presenting with acute hepatitis C and 19 healthy control donors.
Identified and quantified hepatitis C virus–specific CD8+ T cells by measuring interferon-gamma production using enzyme-linked immunospot assays following antigen stimulation.
Patients with a self-limited course exhibited significantly higher numbers of interferon-gamma–producing virus-specific CD8+ T cells during the first 6 months compared to patients who developed chronic infection (P < .001).
Interferon-gamma–producing CD8+ T cell levels in patients with self-limited infection subsequently declined to undetectable levels after the initial 6-month clearance period.

Cite This Study

Grüner et al. (2000) studied this question.

synapsesocial.com/papers/6a704ff8febe604dd7091860 https://doi.org/10.1086/315450

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Implication

Cohort study reveals an association between early CD8+ T cell responses and viral clearance in acute hepatitis C, suggesting cellular immunity drives infection resolution.

Association of Hepatitis C Virus–Specific CD8+T Cells with Viral Clearance in Acute Hepatitis C

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of Hepatitis C Virus–Specific CD8+T Cells with Viral Clearance in Acute Hepatitis C

Discussion

Member takes

Implication

Key Points

Cite This Study

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