Why the study?
Because His-Purkinje fibres are located in the interventricular septum, QRS-prolongation may directly result from septal fibrosis, but whether septal midwall LGE correlates with QRS-duration is unclear.
Does the presence and extent of septal midwall LGE on CMR correlate with QRS duration on ECG in patients with nonischemic dilated cardiomyopathy?
Does the presence and extent of septal midwall LGE on CMR correlate with QRS duration on ECG in patients with nonischemic dilated cardiomyopathy?
In patients with nonischemic dilated cardiomyopathy, QRS prolongation and septal midwall LGE frequently co-exist but are not correlated, suggesting CMR and ECG provide complementary prognostic information.
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Absence of correlation cautions against equating QRS prolongation with septal fibrosis on CMR; leaves open mechanistic links and requires prospective validation in DCM.
Becker et al. (2020) studied this question.
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