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October 1, 1987American Journal of Clinical Pathology

A Novel Whole Blood Capillary Technic for Measuring the Prothrombin Time

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Why the study?

Does a capillary whole blood device using fingerstick samples accurately measure prothrombin time compared to reference plasma PTs in normal volunteers and patients receiving anticoagulants?

Population

732 subjects (193 normal volunteers and 539 patients receiving anticoagulants) providing 858 samples

Comparison

Capillary whole blood device using fingerstick… vs Reference plasma prothrombin time method…

Design

Cross-sectional

Authors

FLFred V. LucasCleveland State UniversityADAlexander DuncanPacific University OregonRJRichard M. JayQueen's University Belfast

Discussion

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Implication

High correlation supports device feasibility for PT testing; leaves open clinical adoption pending prospective validation.

Structured PICO

Does a capillary whole blood device using fingerstick samples accurately measure prothrombin time compared to reference plasma PTs in normal volunteers and patients receiving anticoagulants?

P
Population
732 subjects (193 normal volunteers and 539 patients receiving anticoagulants) providing 858 samples
I
Intervention
Capillary whole blood device using fingerstick samples for measuring prothrombin time
C
Comparator
Reference plasma prothrombin time (PT) method requiring venipuncture
O
Outcome
Prothrombin time (PT) measurement accuracy and correlation between capillary whole blood and reference plasma methodssurrogate

A novel capillary whole blood device using fingerstick samples provides prothrombin time measurements highly correlated with reference plasma methods, potentially enabling point-of-care and patient self-testing.

Cite This Study

Lucas et al. (1987) studied this question.

synapsesocial.com/papers/6a70536e26770c2b8de07702https://doi.org/10.1093/ajcp/88.4.442
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Proficiency Testing and Standardization of Prothrombin Time: Effect of Thromboplastin, Instrumentation, and Plasma1984 · 36 citations