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April 15, 2002BloodOpen Access

Coronary no-reflow is caused by shedding of active tissue factor from dissected atherosclerotic plaque

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Why the study?

Does tissue factor released from atherosclerotic plaque cause coronary no-reflow?

Population

19 human patients, atherosclerotic carotid artery scrapings, and a porcine model

Comparison

Measurement of tissue factor levels in coronary… vs Coronary blood after flow restoration; not…

Design

Preclinical

Authors

DBDiana BondermanHeart Failure / CardiomyopathyATAlexander TemlDr. Margarete Fischer-Bosch-Institute of Clinical PharmacologyJJJohannes JakowitschHeart Failure & Transplant

Discussion

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Implication

Tissue factor may contribute to no-reflow in porcine models; leaves open its causal role after human plaque rupture.

Structured PICO

Does tissue factor released from atherosclerotic plaque cause coronary no-reflow?

P
Population
19 human patients (6 undergoing coronary interventions with distal protection, 13 experiencing coronary no-reflow), atherosclerotic carotid artery scrapings, and a porcine model
I
Intervention
Measurement of tissue factor (TF) levels in coronary blood; intracoronary injection of purified relipidated TF or atherosclerotic material in a porcine model
C
Comparator
Coronary blood after flow restoration (in humans); not explicitly stated for porcine model
O
Outcome
Tissue factor activity and antigen levels in coronary blood; induction of no-reflow in porcine modelsurrogate

Active tissue factor released from dissected coronary atherosclerotic plaque is a major determinant of the coronary no-reflow phenomenon.

Cite This Study

Bonderman et al. (2002) studied this question.

synapsesocial.com/papers/6a70547226770c2b8de077cdhttps://doi.org/10.1182/blood.v99.8.2794

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits2000 · 52 citations
  2. 2Regulation of the Procoagulant Response to Arterial Injury1999 · 45 citations
  3. 3Heightened Tissue Factor Associated With Tissue Factor Pathway Inhibitor and Prognosis in Patients With Unstable Angina1999 · 195 citations
  4. 4The Thrombolysis in Myocardial Infarction (TIMI) Trial1985 · 3,191 citations
  5. 5Endothelium‐dependent contractile actions of proteinase‐activated receptor‐2‐activating peptides in human umbilical vein: release of a contracting factor <i>via</i> a novel receptor1998 · 47 citations