Why the study?
In the absence of data from confirmatory research, real-life data on anticoagulation treatment and clinical outcomes of VTE in patients with renal impairment were needed.
Does severe renal impairment increase the risk of mortality, recurrent VTE, or major bleeding in patients with venous thromboembolism?
Population
2,062 consecutive patients with objectively confirmed VTE
Comparison
Patients with vs without severe renal impairment (estimated creatinine clearance < 30 mL/min)
Design
Registry-based cohort study
Follow-up
90 days
Authors
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Severe RI signals higher 90-day mortality in VTE without excess recurrence or bleeding; leaves open optimal anticoagulation strategies for prospective study.
Does severe renal impairment increase the risk of mortality, recurrent VTE, or major bleeding in patients with venous thromboembolism?
In patients with venous thromboembolism, severe renal impairment is associated with increased 90-day mortality but similar rates of recurrent VTE and major bleeding compared to those without severe renal impairment.
Spirk et al. (2019) studied this question.
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