Why the study?
What are the three-month clinical outcomes in patients with venous thromboembolism and severe renal insufficiency (CrCl <30 ml/min)?
Population
18,251 consecutive patients with acute, objectively confirmed, symptomatic deep vein thrombosis or pulmonary…
Design
Cohort
Follow-up
3 months
Key result
Creatinine clearance <30 ml/min in VTE patients increased mortality; those with PE faced a 9.0% rate of death from initial PE, while those with DVT faced a 3.1% rate of fatal bleeding.
Authors
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VTE patients with CrCl <30 ml/min face PE-driven mortality or bleeding risk by presentation; leaves open tailored strategies in prospective trials.
Observational (n=18,251)
What are the three-month clinical outcomes in patients with venous thromboembolism and severe renal insufficiency (CrCl <30 ml/min)?
In VTE patients with severe renal insufficiency, the primary threat for those presenting with PE is the PE itself, whereas for those presenting with DVT, the primary threat is bleeding.
Falgá et al. (2007) conducted an observational in Venous thromboembolism and renal insufficiency (n=18,251). Creatinine clearance <30 ml/min vs. Creatinine clearance >30 ml/min was evaluated on Fatal bleeding, fatal PE, and overall death. Creatinine clearance <30 ml/min in VTE patients increased mortality; those with PE faced a 9.0% rate of death from initial PE, while those with DVT faced a 3.1% rate of fatal bleeding.
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