Population
3-month-old working mouse hearts from commonly used control mouse substrains SJL/JCrNTac, 129S6/SvEvTac…
Comparison
Ex vivo perfusion with physiological… vs Comparison among the different mouse substrains
Design
Preclinical
Authors
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Mouse strain alters cardiac output and substrate oxidation; leaves open optimal controls for transgenic heart disease models.
Significant variations in cardiac metabolic and functional profiles exist among commonly used control mouse strains, highlighting the critical importance of selecting appropriate control strains for transgenic studies.
Vaillant et al. (2013) studied this question.
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