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August 1, 1984Circulation

Computerized quantitative analysis of left ventricular wall motion by two-dimensional echocardiography.

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Why the study?

Does computerized quantitative analysis using specific reference methods improve the accuracy of detecting left ventricular wall motion abnormalities in patients undergoing two-dimensional echocardiography?

Population

61 subjects (30 normal subjects and 31 'abnormal' patients) undergoing two-dimensional echocardiography

Comparison

Computerized quantitative analysis of left… vs Comparison among the 44 different reference…

Design

Cross-sectional

Follow-up

within 2 days (for a subset of 10 normal subjects)

Authors

ISIngela SchnittgerPFPeter J. FitzgeraldEGElaine Gordon

Discussion

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Overview

May support view-specific references for quantitative LV wall motion analysis; leaves open prospective validation for abnormality detection.

Key Points

  • To assess the feasibility and diagnostic accuracy of computerized quantitative analysis of left ventricular wall motion using multiple reference systems across standard two-dimensional echocardiographic views.
  • Evaluated 44 reference methods (fixed external, floating translation-corrected, and translation-plus-rotation-corrected) across three standard echocardiographic views in 61 subjects.
  • Established 95% confidence intervals from end-diastolic and end-systolic borders in 20 healthy subjects, prospectively testing these thresholds in 10 healthy controls and 31 patients with abnormal wall motion.
  • Assessed reproducibility by repeating echocardiography in 10 healthy subjects within two days, measuring fractional shortening and area changes at intervals between 5 and 45 degrees.
  • A floating-reference system correcting for translation achieved the highest sensitivity and specificity in the apical four-chamber and mitral valve short-axis views, whereas a fixed external reference performed best at the papillary muscle level.
  • Fractional area-change calculations provided identical diagnostic sensitivity and specificity to radial dimension measurements across 5- to 45-degree outline perimeter intervals.
  • Day-to-day variability in mean contraction averaged 7% to 9% for radial shortening methods and 9% to 13% for area-based methods.

Structured PICO

Does computerized quantitative analysis using specific reference methods improve the accuracy of detecting left ventricular wall motion abnormalities in patients undergoing two-dimensional echocardiography?

P
Population
61 subjects (30 normal subjects and 31 'abnormal' patients) undergoing two-dimensional echocardiography
I
Intervention
Computerized quantitative analysis of left ventricular wall motion using 44 different reference methods (including fixed external reference, floating reference correcting for translation, and systems correcting for both translation and rotation)
C
Comparator
Comparison among the 44 different reference methods
O
Outcome
Sensitivity and specificity of different reference methods for detecting left ventricular segmental wall motion abnormalitiessurrogate

The optimal reference method for quantitative analysis of left ventricular wall motion by 2D echocardiography varies by view, with floating-reference systems best for apical and basal views and fixed systems best for mid-ventricular views.

Cite This Study

Schnittger et al. (1984) studied this question.

synapsesocial.com/papers/6a70552775498292b709bfechttps://doi.org/10.1161/01.cir.70.2.242
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantitative left ventricular wall motion analysis: a comparison of area, chord and radial methods.1979 · 245 citations
  2. 2Computerized Quantification Analysis of Left Ventricular Wall Motion from Echocardiograms1997 · 2 citations
  3. 3Application of automatic boundary detection for computerized quantitative analysis of left ventricular regional wall motion by two-dimensional echocardiography1997 · 5 citations
  4. 4Three‐Dimensional Echocardiography for Quantitative Left Ventricular Wall Motion Analysis:1994 · 29 citations
  5. 5Quantitation of left ventricular wall motion in normal subjects: Comparison of various methods1980 · 15 citations