Why the study?
Do volatile anesthetics augment cardiac depression in isolated hearts from guinea pigs chronically treated with amiodarone?
Population
26 isolated hearts from guinea pigs chronically treated with amiodarone or placebo.
Comparison
Exposure to 0.5 and 1 minimum alveolar… vs Placebo-treated isolated hearts and baseline…
Design
Preclinical, Anesthetics administered in random order
Authors
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May indicate additive risks with volatile anesthetics in amiodarone patients; leaves open translation from isolated guinea pig hearts.
Do volatile anesthetics augment cardiac depression in isolated hearts from guinea pigs chronically treated with amiodarone?
Volatile anesthetics additively augment the impairment of conduction and contractility caused by chronic amiodarone therapy in an isolated heart model.
Rooney et al. (1995) studied this question.
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