Population
24 pentobarbitone anaesthetised dogs with acute left anterior descending coronary artery ligation
Comparison
Intravenous amiodarone vs Drug-free controls
Design
Preclinical
Follow-up
15 min after coronary ligation and 15 min after exposure…
Authors
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Low-dose amiodarone may attenuate ischemia-related arrhythmia vulnerability; leaves open optimal dosing in clinical translation.
In a canine model of acute ischemia, low-dose intravenous amiodarone reduced dispersion of repolarization and arrhythmia vulnerability, whereas high-dose amiodarone paradoxically increased both.
Mayuga et al. (1992) studied this question.
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