Why the study?
Does once-daily captopril and hydrochlorothiazide reduce whole-day blood pressure as effectively as twice-daily administration in elderly patients with mild to moderate hypertension?
Does once-daily captopril and hydrochlorothiazide reduce whole-day blood pressure as effectively as twice-daily administration in elderly patients with mild to moderate hypertension?
Once-daily captopril and hydrochlorothiazide effectively reduces whole-day blood pressure in elderly patients, though with slightly less systolic reduction than twice-daily dosing.
No takes yet. Share an insight, caveat, or question.
Once-daily dosing was associated with whole-day BP reductions in elderly hypertensives; leaves open equivalence to twice-daily regimens in randomized trials.
Deanna G. Cheung (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: