Why the study?
Children with obesity have larger adult left ventricular dimensions, but whether this reflects a persistent effect of adiposity into adulthood is confounded across the lifecourse.
Does childhood body size have an independent long-term influence on adulthood heart structure when accounting for adult body size?
Population
Participants in the UK Biobank study
Comparison
Childhood body size vs adult body size
Design
Multivariable mendelian randomization study
Authors
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Childhood adiposity may independently influence adult LV structure; leaves open whether early intervention alters long-term cardiac outcomes.
Does childhood body size have an independent long-term influence on adulthood heart structure when accounting for adult body size?
Childhood body size has a long-term, potentially immutable influence on heart structure in later life, independent of adult body size.
O’Nunain et al. (2022) studied this question.
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