Key result
Childhood body size affected 42 of 123 metabolic markers (P < 4.07 × 10-4), but 35 of these effects substantially attenuated when accounting for adult body size.
Why the study?
Whether childhood adiposity directly impacts intermediate markers of adult disease risk independently of adult adiposity is unclear.
Does childhood adiposity directly impact adult systemic metabolic markers independently of adult adiposity?
Population
Up to 24 925 adults for metabolic markers and 60 801 CAD cases and 123 504 controls
Comparison
Childhood body size accounting for adult body size
Design
Two-sample and multivariable Mendelian randomization study
Authors
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Childhood adiposity effects on biomarkers largely attenuate after adult size adjustment; leaves open independent causal pathways for select markers.
Observational (n=209,230)
Does childhood adiposity directly impact adult systemic metabolic markers independently of adult adiposity?
p-value: p=< 4.07 × 10-4
Childhood adiposity affects adult systemic metabolism and CAD risk predominantly through its influence on adulthood body size, rather than via direct independent effects.
Richardson et al. (2021) conducted an observational in Childhood adiposity and adult systemic metabolism (n=209,230). Childhood body size was evaluated on 123 nuclear magnetic resonance-based metabolic markers (p=< 4.07 × 10-4). Childhood body size affected 42 of 123 metabolic markers (P < 4.07 × 10-4), but 35 of these effects substantially attenuated when accounting for adult body size.
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