August 1, 2019MedicineOpen Access

Childhood obesity leads to adult type 2 diabetes and coronary artery diseases

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Why the study?

Observational studies show childhood obesity is associated with adult T2D and CAD, but whether this association is causal remained unclear.

Does genetic predisposition to childhood obesity increase the risk of adult type 2 diabetes and coronary artery disease?

Population

Summary-level data of large-sample genome-wide association studies

Comparison

Genetic predisposition to childhood obesity vs lower genetic predisposition

Design

Two-sample Mendelian randomization study

Authors

XFXuqian FangShanghai Jiao Tong University JZJunli ZuoShanghai Jiao Tong University JZJingqi ZhouShanghai Jiao Tong University

Discussion

Member takes

Implication

Should not yet change pediatric obesity management; leaves open whether early intervention reduces adult T2D/CAD.

Structured PICO

Does genetic predisposition to childhood obesity increase the risk of adult type 2 diabetes and coronary artery disease?

Population

Summary-level data from large-sample genome-wide association studies (GWAS) of individuals of European ancestry, including 26,488 cases and 83,964 controls for type 2 diabetes (DIAGRAM consortium), and 60,801 cases and 12,354 controls for coronary artery disease (CARDIoGRAMplusC4D consortium).

Intervention

Genetic predisposition to childhood obesity (using 7 or 9 single-nucleotide polymorphisms as instrumental variables)

Comparator

Lower genetic predisposition to childhood obesity

Outcome

Adult type 2 diabetes (T2D) and coronary artery disease (CAD)hard clinical

A genetic predisposition to childhood obesity is causally associated with an increased risk of adult type 2 diabetes and coronary artery disease, as well as adverse cardiometabolic traits.

Limitations

Genetic variants applied in the MR analysis are weak instruments, potentially lowering statistical power for null associations
Potential confounders such as population stratification and timing for exposure may influence results
Largely dependent on summary level data from GWAS performed in populations of European ancestry, limiting generalizability to other ethnicities

Cite This Study

Fang et al. (2019) studied this question.

synapsesocial.com/papers/6a7dff7bb3178841a7999d34 https://doi.org/10.1097/md.0000000000016825

Topics

Coronary artery disease

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Childhood obesity leads to adult type 2 diabetes and coronary artery diseases

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Childhood obesity leads to adult type 2 diabetes and coronary artery diseases

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider