Key result
Childhood obesity increased the risk of heart failure (OR 1.11; 95% CI 1.05-1.17; p=1.26x10^-4), type 2 diabetes, atrial fibrillation, myocardial infarction, and coronary artery disease.
Why the study?
Observational studies show obesity affects the cardiovascular system, prompting evaluation of the causal effect of childhood obesity on heart failure and its risk factors.
Does genetically predicted childhood obesity increase the risk of heart failure and its associated risk factors in the European population?
Population
European population from GWAS datasets
Comparison
Genetically predicted childhood obesity vs non-obesity
Design
Mendelian randomization study
Authors
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May support early obesity prevention to lower later HF and CV risks; extends MR evidence but remains hypothesis-generating.
Observational
Does genetically predicted childhood obesity increase the risk of heart failure and its associated risk factors in the European population?
Odds Ratio: 1.11 (95% CI 1.05–1.17)
p-value: p=1.26 × 10^-4
Mendelian randomization provides genetic evidence that childhood obesity causally increases the risk of heart failure and related cardiovascular risk factors.
Kong et al. (2023) conducted an observational in Childhood obesity. Childhood obesity vs. Absence of childhood obesity was evaluated on Heart failure (HF) (OR 1.11, 95% CI 1.05-1.17, p=1.26 × 10^-4). Childhood obesity increased the risk of heart failure (OR 1.11; 95% CI 1.05-1.17; p=1.26x10^-4), type 2 diabetes, atrial fibrillation, myocardial infarction, and coronary artery disease.
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