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November 14, 2025Pediatric Obesity

Childhood Obesity and Age‐Related Diseases: A Systematic Review and Meta‐Analysis of Mendelian Randomization Evidence

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Authors

HZHaoxue ZhuXYXinghao YiMHMengyu He

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Overview

Meta-analysis reveals childhood obesity increases risk of 16 age-related diseases, suggesting urgent obesity prevention measures needed.

Key Points

  • To investigate causal associations between childhood obesity and age-related diseases using Mendelian randomization.
  • Systematic review and meta-analysis of 45 MR articles
  • Analyzed genetic data from UK Biobank and FinnGen
  • Explored associations of childhood obesity with various age-related diseases
  • Identified 16 diseases associated with genetically determined childhood obesity
  • Found suggestive links with hypertension, cancer, diabetes, and more
  • Noted paradoxical associations for breast cancer and ulcerative colitis

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/692519acc0ce034ddc35428fhttps://doi.org/10.1111/ijpo.70071
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