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April 1, 2017EchocardiographyOpen Access

Regional right ventricular remodeling and function in children with idiopathic pulmonary arterial hypertension vs those with pulmonary valve stenosis: Insights into mechanics of right ventricular dysfunction

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Population

52 children

Design

Cohort

Authors

MDM. M. P. DriessenErasmus MCFMFolkert J. MeijboomAdult Congenital Heart DiseaseWHWei HuiPediatric Cardiology

Discussion

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Implication

RV mechanics differ in pediatric PS vs iPAH; leaves open markers of dysfunction and prognostic mechanisms.

Structured PICO

P
Population
52 children (18 with idiopathic pulmonary arterial hypertension [iPAH], 16 with pulmonary valve stenosis [PS], and 18 controls)
C
Comparator
Controls and children with pulmonary valve stenosis
O
Outcome
Right ventricular mechanics (global and regional RV remodeling, systolic function, longitudinal deformation, transverse shortening)surrogate

Children with iPAH exhibit more severe adverse global and regional RV remodeling and mechanics, including decreased longitudinal and transverse shortening, compared to those with pulmonary stenosis.

Cite This Study

Driessen et al. (2017) studied this question.

synapsesocial.com/papers/6a7058cf439bab0cabc32136https://doi.org/10.1111/echo.13529

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension2007 · 756 citations
  2. 2Relationship of Pulmonary Arterial Capacitance and Mortality in Idiopathic Pulmonary Arterial Hypertension2006 · 416 citations
  3. 3Left ventricular systolic function assessment in secondary mitral regurgitation: left ventricular ejection fraction vs. speckle tracking global longitudinal strain2015 · 105 citations
  4. 4THE NATURAL HISTORY OF ISOLATED PULMONARY STENOSIS1965 · 35 citations
  5. 5Adverse ventricular-ventricular interactions in right ventricular pressure load: Insights from pediatric pulmonary hypertension versus pulmonary stenosis2016 · 29 citations