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June 1, 2016Physiological ReportsOpen Access

Adverse ventricular-ventricular interactions in right ventricular pressure load: Insights from pediatric pulmonary hypertension versus pulmonary stenosis

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Population

52 pediatric subjects, including 18 with idiopathic pulmonary arterial hypertension, 16 with pulmonary…

Design

Cohort

Authors

MDM. M. P. DriessenErasmus MCWHWei HuiPediatric CardiologyBBBart BijnensCardiac Imaging

Discussion

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Implication

Worse biventricular interactions in pediatric iPAH than PS warrant caution extrapolating PS data; leaves open mechanisms for prospective validation.

Structured PICO

P
Population
52 pediatric subjects, including 18 with idiopathic pulmonary arterial hypertension (iPAH), 16 with pulmonary stenosis (PS), and 18 age- and size-matched controls.
O
Outcome
Cardiac cycle events (ventricular-ventricular interactions) measured by M-mode and Doppler echocardiographysurrogate

Pediatric patients with idiopathic pulmonary arterial hypertension exhibit more profound adverse ventricular-ventricular interactions, including prolonged RV free wall contraction and septal dyskinesia, compared to those with pulmonary stenosis, independent of RV systolic pressure.

Cite This Study

Driessen et al. (2016) studied this question.

synapsesocial.com/papers/6a7058cf439bab0cabc32137https://doi.org/10.14814/phy2.12833
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impaired Left Ventricular Mechanics in Pulmonary Arterial Hypertension2013 · 126 citations
  2. 2Right ventricular free wall pacing improves cardiac pump function in severe pulmonary arterial hypertension: a computer simulation analysis2009 · 53 citations
  3. 3Improvement in left ventricular filling properties after relief of right ventricle to pulmonary artery conduit obstruction: contribution of septal motion and interventricular mechanical delay2009 · 105 citations
  4. 4Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart2009 · 77 citations
  5. 5Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure2009 · 513 citations