Why the study?
Does weight loss via a very-low-calorie diet affect the activity and expression of adipose-tissue lipoprotein lipase in very obese humans?
Population
9 very obese subjects, mean initial weight 136 +/- 7.3 kg, mean BMI 43.0 +/- 2.5
Comparison
Weight reduction program via very-low-calorie diet vs Baseline (before weight loss)
Design
Cohort
Follow-up
After weight loss, when weight had been stable for three…
Authors
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May impede sustained weight loss in obesity; hypothesis-generating and requires prospective confirmation.
Does weight loss via a very-low-calorie diet affect the activity and expression of adipose-tissue lipoprotein lipase in very obese humans?
Weight loss in very obese subjects leads to increased activity and expression of adipose-tissue lipoprotein lipase, potentially enhancing lipid storage and making further weight loss more difficult.
Kern et al. (1990) studied this question.
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